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Patients with severe deficiency may need more frequent injections initially, while those using B12 for wellness optimization may maintain results with monthly treatments

I've also read about once the process is overridden by saturation of B12 there's no going back to the natural process that was failing anyway

According to the NIH Office of Dietary Supplements, vitamin B12 is available as cyanocobalamin and hydroxocobalamin, which are typically administered parenterally by intramuscular injection to bypass gastrointestinal absorption barriers

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However, substantial heterogeneity among studies was observed, likely attributable to differences in dosage, baseline B12 status, and population characteristics